Urolithin C属于多酚类，是鞣花酸的肠道微生物代谢产物，具有胰岛素分泌的葡萄糖依赖性激活活性。Urolithin C是 L 型Ca2+通道开放剂，可增强Ca2+的流入。它通过线粒体介导的途径诱导细胞凋亡，并刺激活性氧的形成。

Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.

Urolithin C is a glucose-dependent activator of insulin secretion acting by facilitating L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.Urolithin C enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS-1 β-cells[2]. Urolithin C stimulates reactive oxygen species (ROS) formation[2].

In male Wistar rat, the half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) is 0.831 L/kg and the steady-state volume of distribution (Vss/F) is 55.6 L/kg after the intraperitoneal administration of Urolithin C (10 mg/kg)[3].

165393-06-6

C13H8O5

244.202

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years