Fedratinib hydrochloride hydrate 是一种选择性的,ATP 竞争性和具有口服活性的JAK2抑制剂,对于JAK2和JAK2V617F激酶的IC50均为 3 nM。它可诱导癌细胞凋亡,可研究骨髓增生性疾病。
产品描述
Fedratinib hydrochloride hydrate is a potent, selective, ATP-competitive and orally active JAK2 inhibitor.
Cas No.
1374744-69-0
分子式
C27H40Cl2N6O4S
分子量
615.62
别名
TG-101348 hydrochloride hydrate;SAR 302503 hydrochloride hydrate
储存和溶解度
H2O:97 mg/mL (157.56 mM),Need ultrasonic
DMSO:120 mg/mL (194.92 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years