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Maprotiline hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Maprotiline hydrochloride图片
CAS NO:10347-81-6
包装与价格:
包装价格(元)
100 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Psymion
盐酸马普替林
Deprilept
Ludiomil
Maprotiline HCl
产品介绍
Maprotiline hydrochloride 是一种桥环四环类抗抑郁药,是去甲肾上腺素重吸收抑制剂。

产品描述

Maprotiline hydrochloride is a bridged-ring tetracyclic antidepressant that is both mechanistically and functionally similar to the tricyclic antidepressants, including side effects associated with its use.

体外活性

Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. [1] Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. [2] Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum. [3]

体内活性

Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. [4] Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. [5] Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training. [6]

Cas No.

10347-81-6

分子式

C20H24ClN

分子量

313.87

别名

Psymion;盐酸马普替林;Deprilept;Ludiomil;Maprotiline HCl

储存和溶解度

H2O:<1 mgml
DMSO:59 mg/mL (188 mM)
Ethanol:23 mg/mL (73.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years