Astemizole 是一种长效、非镇静抗组胺药，用于治疗季节性过敏性鼻炎、哮喘、过敏性结膜炎和慢性特发性荨麻疹。它是组胺 H1 受体的拮抗剂，IC50值为 4 nM，还阻断HERG K+通道，IC50值为 0.9 nM，具有抗胆碱能和止痒作用。

Astemizole is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria.

68844-77-9

C28H31FN4O

458.581

Paralergin;阿司咪唑;Histaminos;Laridal

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years