SUN 1334H is a potent, orally active, highly selective antagonist of H1 receptor(Ki of 9.7 nM).

In CHO-K1/hERG cells,SUN-1334H causes potent inhibition of histamine induced contractions of isolated guinea-pig ileum(IC50 : 0.198 μM)[2].

In beagle dogs and ovalbumin-induced rhinitis in guinea pigs, SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal [1]. SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions in skin allergy models. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects[2].

607736-84-5

C23H28Cl2F2N2O3

489.38

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years