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SCH 563705
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SCH 563705图片
CAS NO:473728-58-4
包装与价格:
包装价格(元)
5 mg电议
10 mg电议

产品介绍

产品描述

SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).

体外活性

SCH 563705 potently inhibits mouse CXCR2 (IC50 = 5.2 nM). SCH 563705 displays potent inhibition against both Gro-a and IL-8 induced human neutrophil migration (chemotaxis IC50 = 0.5 nM, against 30 nM of Gro-a; chemotaxis IC50 = 37 nM, against 3 nM of IL-8) [1][2].

体内活性

SCH 563705 has good oral pharmacokinetic profiles in rats, mice, monkeys, and dogs. SCH563705 (3-30 mg/kg p.o) treatment causes a dose-dependent elevation in plasma levels of CXCL1. SCH 563705 (50 mg/kg p.o) decreases blood Ly6G+ Ly6C+ neutrophil frequency and unchanged levels of Ly6GLy6Chi monocytes [1][2].

Cas No.

473728-58-4

分子式

C23H27N3O5

分子量

425.48

储存和溶解度

DMSO:30 mg/mL (70.51 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years