HERnandezine 是 AMPK 激动剂的激动剂，也是癌细胞中 ABCB1 介导的 MDR 的特异性逆转剂。

Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.

Hernandezine inhibits LPS-induced TNF-α expression/production in human macrophage cell lines (THP-1 and U93). Hernandezine inhibits the transport function of ABCB1, and enhances drug-induced apoptosis in cancer cells. Hernandezine significantly resensitizes ABCB1-overexpressing cancer cells to multiple chemotherapeutic drugs at nontoxic, nanomolar concentrations[1].

6681-13-6

C39H44N2O7

652.78

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years