DAPTA 是一种合成肽，是CCR5抑制剂，有抗 HIV 的活性。

DAPTA(TFA) is an inhibitor of CCR5, shows potent anti-HIV activities.

D-Ala-peptide T-amide (DAPTA), or Peptide T, named for its high threonine content (ASTTTNYT), is a synthetic peptide comprised of eight amino acids (185-192) of the gp120 V2 region and functions as a viral entry inhibitor by targeting selectively CCR5.?The anti-HIV-1 activity of DAPTA was evaluated in M/M infected with R5 HIV-1 strains.?DAPTA at 10(-9) M inhibited HIV-1 replication in M/M by >90%.?PCR analysis of viral cDNA in M/M showed that DAPTA blocks HIV entry and in this way prevents HIV-1 infection.?Moreover, DAPTA acts as a strong inhibitor and was more active than the non-peptidic CCR5 antagonist TAK-779 in inhibiting apoptosis (mediated by RS HIV-1 strains produced and released by infected M/M) on a neuroblastoma cell line[1]

106362-34-9

C35H56N10O15

856.888

Adaptavir;D-Ala-peptide T-amide;DAPTA(TFA)

DMSO:10mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years