Tyrphostin A1 对巨噬细胞培养中CD40L刺激的IL-12产生和抗原诱导的Th1细胞生成具有抑制作用。

Tyrphostin A1 is an inhibitor of EGFR tyrosine kinase .

Tyrphostin A1 inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.tyrphostin A1 blocks CD40L-induced translocation of NF-kappaB to the nucleus, and reduces the activation of IL-12 p40 gene.?In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells[1].

2826-26-8

C11H8N2O

184.198

AG9;(4-甲氧基苄烯)丙二腈;Tyrphostin 1

DMSO:100 mg/mL (542.92 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years