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Setipiprant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Setipiprant图片
CAS NO:866460-33-5
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
ACT-129968
塞替匹仑
KYTH-105
产品介绍
Setipiprant 是一种口服的选择性 CRTH2 拮抗剂,IC50为6.0 nM。

产品描述

Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.

Cas No.

866460-33-5

分子式

C24H19FN2O3

分子量

402.425

别名

ACT-129968;塞替匹仑;KYTH-105

储存和溶解度

DMSO:36 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years