ONO-AE3-208 是一种 EP4 拮抗剂，可抑制前列腺癌的细胞迁移、侵袭和转移。

ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.

ONO-AE3-208 abolishes CTGF in the presence of the EET synthesis inhibitor MS-PPOH. Arachidonic acid causes the dose-dependent dilation of the attached Af-Art, and this effect is blocked by ONO-AE3-208 [2].

In mice, ONO-AE3-208 suppresses the in vivo bone metastasis of PC3 cells [1]. The photon tumor burdens are significantly increased in a time-dependent manner in the control group in comparison with those in the ONO-AE3-208-treated group. The rate of metastasis formation is significantly higher in the former than in the latter. The median time of metastasis formation is 29 d in the ONO-AE3-208-treated animals as compared with 21 d in the controls [3].

402473-54-5

C24H21FN2O3

404.43

AE 3-208

DMSO:40 mg/mL (98.9 mM)
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years