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Laropiprant
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Laropiprant图片
CAS NO:571170-77-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
MK-0524
产品介绍
Laropiprant 是DP receptor的选择性拮抗剂,Ki为 0.57 nM,对 TP 受体的Ki为 2.95 nM。

产品描述

Laropiprant is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).

体外活性

Laropiprant blocks DP receptor-dependent enhance in VASP phosphorylation, as well as inhibition of P-selectin expression, GPIIb/IIIa activation, and in vitro thrombus formation. Laropiprant antagonizes the increased platelet aggregation by TP and EP3 receptor activation. Laropiprant (1 μM) induces a significant inhibition of the aggregation but still counteracts the pronounced inhibition caused by PGD2 (30 nM) and BW245c (3 nM). Laropiprant (10 μM) and niacin inhibit in vitro thrombus formation[2].

Cas No.

571170-77-9

分子式

C21H19ClFNO4S

分子量

435.9

别名

MK-0524

储存和溶解度

DMSO:100 mg/mL (229.41 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years