STA21 是一种天然抗生素，也是一种STAT3抑制剂。它可抑制STAT3DNA结合活性，STAT3二聚化。它具有抗癌和抗菌活性。

STA-21 is a selective STAT3 inhibitor.

In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. [1] In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways. [2]

In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3. [3]

Human breast cancer cell lines MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, and MCF7, human ovarian carcinoma cell line Caov-3, and human skin fibroblasts were cultured in DMEM containing 10% FBS and appropriate antibiotics in a 5% CO2 incubator at 37°C. For testing different compounds, the cells were exposed to the compounds for 48 h at a final concentration of 20 or 30 μM, respectively. Then, the cells were harvested and subjected to flow-cytometry analysis.(Only for Reference)

111540-00-2

C19H14O4

306.317

STA-21;STA 21;STA21

DMSO:20 mg/mL (65.3 mM)
H2O:<1 mgml
Ethanol:2 mg/mL (6.52 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years