Alsterpaullone 是高效的CDK抑制剂，是一种 ATP 竞争性的 GSK-3alpha/GSK-3beta 抑制剂，且作用的IC50值都为 4 nM。它有用于神经退行性和增生性疾病的研究潜力，具有抗肿瘤活性，诱导白血病细胞凋亡。

Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec

Alsterpaullone inhibited HeLa cells in a time-dependent (0-72 h) and dose-dependent (0-30 μ M) manner.?In the presence of alsterpaullone, HeLa cells were arrested in G2/M prior to undergoing apoptosis via a mechanism that is involved in the regulation of various antiapoptotic genes, DNA-repair, transcription, and cell cycle progression.?Compared to controls, alsterpaullone effectively prevented HeLa cells from entering S-phase.?These potential therapeutic efficacies could be correlated with the activation of caspase-3[1].

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C16H11N3O3

293.282

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years