ABC99是wnt脱酰基酶的一种选择性不可逆抑制剂。ABC99抑制NOTUM（IC50:13 nM）。它还显示了对丝氨酸水解酶家族的优良选择性。

ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family.

ABC99 (0.1~10 μΜ; 2 hours; SW620 cells) inhibits NOTUM in a concentration-dependent manner and preserves Wnt-3A activity in the presence of NOTUM in a concentration-dependent manner[1].

2331255-53-7

C22H21ClN4O5

456.88

ABC 99

DMSO:20 mg/mL (43.8 mM),ultrasonic and heat to 80°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years