MSAB 是一种Wnt/β-CATenin信号传导的选择性抑制剂。它能够与 β-CATenin 结合，诱导其降解，并能够下调 Wnt/β-CATenin 靶基因。它对 Wnt 依赖性癌细胞表现出有效的抗肿瘤特性。

MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.

MSAB act against Wnt/β-catenin signaling and identified ?as a selective inhibitor of Wnt/β-catenin signaling.?MSAB shows potent anti-tumor effects selectively on Wnt-dependent cancer cells in vitro and in mouse cancer models.?MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.?might represent an effective therapeutic strategy for cancers addicted to the Wnt/β-catenin signaling pathway.

173436-66-3

C15H15NO4S

305.35

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years