ISX-9 是一种神经干细胞分化的有效诱导剂，可诱导 Notch 激活的心外膜衍生细胞 (NEC) 的心肌分化。它可通过电压门控的 Ca2+通道和 NMDA 受体来激活 Ca2+流入，并增加 NeuroD 表达。

ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.

In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. [1]

In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. [2]

Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.(Only for Reference)

832115-62-5

C11H10N2O2S

234.27

Isoxazole 9;Isoxazole 9 (ISX-9)

Ethanol:11 mg/mL (47 mM)
DMSO:43 mg/mL (183.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years