Pyrvinium pamOATe 是一种古老的驱虫药，用于治疗蛲虫病，由于其在某些类型的癌症中抑制 Wnt/β-CATenin 通路，它作为抗癌药物再次引起人们的关注。

Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types of cancer.

Pyrvinium pamoate treatment repressed the phosphorylation of GSK3β at S9 which might be mediated by AKT, and decreased the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). Pyrvinium pamoate remarkably inhibited cell viability and colony formation ability. Treatment with pyrvinium pamoate induced intrinsic pathway-dependent apoptosis accompanied with a decline of anti-apoptotic XIAP and Survivin, and an overt increase of pro-apoptotic Bax. In addition, pyrvinium pamoate significantly inhibited the migration and invasion in vitro[1].

3546-41-6

C75H70N6O6

1151.421

扑蛲灵;Pyrvinium embonate

DMSO:24 mg/mL (41.69 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years