ICG001 是β-CATenin/TCF介导的一种转录抑制剂，选择性地阻断 β-CATenin/CBP 相互作用而不干扰 β-CATenin/p300 相互作用。它可特异性结合 CREB 蛋白，IC50为3 μM。

ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.

780757-88-2

C33H32N4O4

548.643

DMSO:100 mg/mL (182.27 mM)
Ethanol:9 mg/mL(16.4 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years