CUR61414 是 Hedgehog 信号通路的细胞渗透性抑制剂 (IC50 = 100-200 nM)，并选择性地结合 Smoothened (Ki = 44 nM)。

CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).

CUR61414 arrests the proliferation of basal cells within the BCC-like lesions and induces cell apoptosis and complete regression of the lesions, without affecting neighboring non-tumor cells[1].

CUR61414 regresses these lesions in the mice exposed to UV light irradiation and produces many microscopic BCC-like basaloid lesions throughout their skin[1].

334998-36-6

C31H42N4O5

550.69

DMSO:90.9mg/mL (165.1mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years