| CAS NO: | 2061344-88-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| Molecular Weight (MW) | 590.14 |
|---|---|
| Formula | C20H30ClN3O2S3.CF3COOH |
| CAS No. | 1469337-95-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 100 mg/mL (169.5 mM) |
| Water: 100 mg/mL (169.5 mM) | |
| Ethanol: 100 mg/mL (169.5 mM) | |
| Other info | Chemical Name:
1-[2-[(4-Chlorophenyl)thio]acetyl]-N-[2-[[2-(dimethylamino)ethyl]dithio]ethyl]-4-piperidinecarboxamide
2,2,2-trifluoroacetate InChi Key: YNMYIJSFFJXIRV-UHFFFAOYSA-N InChi Code: InChI=1S/C20H30ClN3O2S3.C2HF3O2/c1-23(2)12-14-29-28-13-9-22-20(26)16-7-10-24(11-8-16)19(25)15-27-18-5-3-17(21)4-6-18;3-2(4,5)1(6)7/h3-6,16H,7-15H2,1-2H3,(H,22,26);(H,6,7) SMILES Code: O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F |
| Synonyms | 6 H 05 TFA; 6 H 05 TFA salt; 6H05 TFA; 6H05 TFA salt; 6-H-05 TFA; 6-H-05 TFA salt; K-Ras(G12C) inhibitor 6H05 |
| In Vitro | In vitro activity: 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras. Furthermore, 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors. Cell Assay: Although it’s necessary to perform continued chemical optimization of 6H05 to be assessed in vivo, preliminary evaluation of 6H05 in lung cancer cell lines suggests that 6H05 shows allele-specific impairment of K-Ras function[1]. There are questions still need to be illustrated that the selectivity and efficiency of 6H05 in vivo, as well as its effects on the subcellular localization of other farnesylated GTPases should be assessed further. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Nature. 2013 Nov 28;503(7477):548-51; Med Res Rev. 2014 Nov;34(6):1242-85. |
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