Fenbufen 是一种非甾体抗炎药，主要用于治疗骨关节炎、强直性脊柱炎和肌腱炎的炎症。它还可用于缓解背痛、扭伤和骨折，具有 Caspases 的抑制活性。它对COX-1和COX-2具有抑制活性，其IC50分别为 3.9 μM 和 8.1 μM。

Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.

Fenbufen and its metabolites could be involved in mitochondrial toxicity through inhibition of ATP synthesis[1]. Fenbufen inhibited prostaglandin release by 80% and reduced rates of protein synthesis in normal muscle and in muscle undergoing hypertrophy in response to tenotomy of a synergist[3].

36330-85-5

C16H14O3

254.285

芬布芬;CL-82204;Lederfen

Ethanol:47 mg/mL (184.8 mM)
H2O:<1 mgml
DMSO:47 mg/mL (184.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years