TJ191 是一种选择性抗癌试剂，靶向低 TβRIII 表达的恶性T细胞白血病/淋巴瘤细胞，可研究癌症。

TJ191 is a selective anti-cancer agent, targeting low TβRIII-expressing malignant T-cell leukemia/lymphoma cells.

TJ191 (0.1-3 μM; 8 or 24 hours) induces CEM cell apoptosis in a concentration- and time-dependent manner. Even at 0.3 μM, TJ191 induces the maximum apoptotic rate of 80% after 24 h.?TJ191(0-100 μM; 24 hours) exhibits pronounced anti-proliferative activity in malignant cell lines, the IC50 values are 0.13 μM, 0.13±0.08 μM, 0.26±0.19 μM, 0.22±0.11 μM, 1.5±0.02 μM, 0.32±0.086 μM, 3.1±0.5 μM, 0.26±0.16 μM in CEM, JURKAT, MOLT-3, MOLT-4, SUP-T1, MT-2, C8166 and HSB-2 cells, respectively. But has no effects in HUT-78 (IC50=17±10 μM) and MT-4 (IC50=47 ± 5 μM) cells.

1522415-97-9

C13H21NO2S

255.38

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years