LY 303511 hydrochloride 是LY294002 的一种结构类似物。LY303511 可增强 SHEP-1 神经母细胞瘤细胞的TRAIL敏感性，还可逆地阻断 MIN6 胰岛瘤细胞中的K+电流。

LY303511 (NV-128)is a potent mTOR inhibitor

LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms.

2070014-90-1

C19H19ClN2O2

342.82

LY303511 hydrochloride

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years