MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).

MI-1061 achieves IC50 of 100 and 250 nM in the SJSA-1 and HCT-116 p53+/+ cell lines, respectively[1].

MI-1061 was able to achieve tumor regression in oral SJSA-1 xenograft model mice[1].

1410737-34-6

C30H26Cl2FN3O4

582.45

DMSO:300 mg/mL (515.07 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years