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ML311
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML311图片
CAS NO:315698-17-0
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议

产品介绍
ML311 是 Mcl-1/Bim 相互作用的一种选择性抑制剂。

产品描述

ML311 is a selective inhibitor of the Mcl-1/Bim interaction.

体外活性

ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50: 0.31 μM), NCI-H929 (EC50: 1.6 μM), and DHL-6 (EC50: 3.3 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50: 1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and<2 μM for 14 additional types[1].

Cas No.

315698-17-0

分子式

C23H24F3N3O

分子量

415.46

储存和溶解度

H2O:Insoluble
DMSO:20 mg/mL
Ethanol:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years