S55746 是一种有效、可口服、选择性的BCL-2抑制剂，其Ki值和Kd值分别为 1.3 nM 和 3.9 nM。它具有抗肿瘤活性且毒性低。

S55746 is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).

S55746 selectively causes apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner. S55746 (0-1 μM) effectively and selectively induces cell death [1].

S55746 is a highly efficacious and well-tolerated (even at doses up to 300 mg/kg) orally active BCL-2 inhibitor. S55746 (20-100 mg/kg, p.o.) inhibits xenograft growth in RS4 [1].

1448584-12-0

C43H42N4O6

710.82

BLC201

DMSO:44 mg/mL (61.9 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years