S63845 是一种选择性骨髓细胞白血病 1 抑制剂，结合人MCL1的Kd值为 0.19 nM。

S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)

S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1.?S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway[1].

In vivo, S63845 shows potent anti-tumour activity with an acceptable safety margin as a single agent in several cancers.?Moreover, MCL1 inhibition, either alone or in combination with other anti-cancer drugs, proved effective against several solid cancer-derived cell lines.?MCL1 as a target for the treatment of a wide range of tumours[1].

1799633-27-4

C39H37ClF4N6O6S

829.26

DMSO:33.33 mg/mL (40.19 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years