Piperazine ERastin 是eRastin的类似物。它会导致一种铁依赖形式的非凋亡性细胞死亡，称为铁死亡。

Piperazine erastin is an analog of erastin. It causes an iron-dependent form of non-apoptotic cell death termed ferroptosis.

Piperazine erastin is affected similarly by cell death modulators as erastin and displays a distinct pattern from other non-FIN lethal compounds. Piperazine erastin is a more effective analog of erastin which is more water-soluble (0.086 mM for erastin versus 1.4 mM for piperazine erastin) and more metabolically stable [1].

A significant delay in tumor growth is observed in the piperazine erastin-treated group compared to the vehicle-treated group, in the xenograft mouse model. Ptgs2 is upregulated in mouse liver with piperazine erastin (10 or 60 mg/kg) administration[1].

1538593-71-3

C35H41ClN6O4

645.19

DMSO:33.33 mg/mL (51.66 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years