Nicardipine hydrochloride 是一种钙通道阻滞剂，IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩，从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。

Nicardipine Hydrochloride is the hydrochloride salt form of nicardipine, a synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator.

Nicardipine可显著降低自发性高血压大鼠的收缩压.在自发性高血压大鼠体内,Nicardipine显著降低了脑动脉和小软膜动脉水平的血管中膜厚度,且增加了管腔面积.Nicardipine使SHR体内枕叶皮质和额叶皮层的神经元数量增多,并对GFAP-阳性的星形胶质细胞增生肥大具有抑制效果.Nicardipine使海马体CA1区的神经元数目增多,并使星形胶质细胞灰质和白质的大小和数量减少. Nicardipine（5 mg/kg）与氟桂嗪（80 mg/kg）和Nimodipine（80 mg/kg）联用,可显著增强乙琥胺（50 mg/kg）或丙戊酸（100 mg/kg）对小鼠阵挛性发作的保护作用. Nicardipine（40 mg/kg,2次/天,共8周）能够减少49.2％的兔子体内斑块面积（胆固醇喂养）.Nicardipine（40 mg/kg）能使胆固醇喂养兔子体内的主动脉胆固醇积累减少74.5%.Nicardipine（100 mg/kg）会使猫的视网膜血流量显著短暂的降低.尽管Nicardipine（100 mg/kg）会降低猫体内平均动脉血压,但会明显增加ONH的血流量,表明Nicardipine有益于视神经发育不全组织.

54527-84-3

C26H30ClN3O6

515.99

RS-69216;YC-93 Hydrochloride;盐酸尼卡地平;Nicardipine HCl

Ethanol:<1 mgml
DMSO:93 mg/mL (180.2 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years