Rocuronium Bromide 是一种氨基甾体类的、非去极化的神经肌肉受体抑制剂，也是一种肌肉松弛剂。

Rocuronium is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.

Rocuronium reduced the indirectly elicited twitch tensions in normal (IC50: 9.84 μM) and all pretreated diaphragms (P< .01, n = 6) in a concentration-dependent fashion [1]. The ED95 of rocuronium is essentially the same for children as for adults. Its duration of action is similar to vecuronium, and it is shorter for children than for adults. Rocuronium is readily reversed with conventional doses of cholinesterase-inhibiting drugs [2]. Onset time until maximum block, duration until 25% recovery of twitch height, and recovery from 25 until 75% of twitch height were 1.7 (32), 53 (19) and 20 (37) min, respectively [3].

119302-91-9

C32H53BrN2O4

609.68

ORG 9426;ORG 9426 (Bromide);罗库溴铵

H2O:112 mg/mL (183.7 mM)
DMSO:113 mg/mL (185.3 mM)
Ethanol:113 mg/mL (185.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years