MRZ 2-514 是 NMDA receptor(glycineB) 的拮抗剂，Ki=33 μM。

MRZ 2-514 is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.

MRZ 2-514 against peak AMPA-induced currents with IC50 values of 72.7 μM[1].

In mice, MRZ 2-514 has anticonvulsive action in the MES model, and the effect is prolonged by probenecid[1].

202808-11-5

C11H6BrN3O3

308.09

8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one

DMSO:18.33 mg/ml (59.51 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years