Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a sustained pharmacokinetic (PK) and pharmacodynamic (PD) characteristics. Atabecestat (JNJ-54861911) has the potential for Alzheimer's Disease treatment[1].

1200493-78-2

C18H14FN5OS

367.4

JNJ-54861911

DMSO:250 mg/mL (680.46 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years