Tradipitant 是一种有效的神经激肽-1 拮抗剂。

Tradipitant is an antagonist of neurokinin-1.

Tradipitant binds to sections of guinea pig brain with a distribution similar to that previously reported for NK-1 receptors. Areas with the highest density are the accessory olfactory nucleus, anteroventral thalamic nucleus, paraventricular hypothalamic nucleus central amygdaloid nucleus (lateral), and the medial amygdaloid nucleus [1].

Tradipitant (intravenously administered) treatment localizes in the guinea pig brain and has a distribution similar to that described for the NK-1 receptor using agonist or antagonist radioligands [1].

622370-35-8

C28H16ClF6N5O

587.9

VLY-686;LY686017

DMSO:60 mg/ml (102.06 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years