SB 218795 是一种有效的特异性 NK3 拮抗剂，对 hNK3 的 Ki 为 13 nM，比 hNK2 和 hNK1 的特异性高约 90 倍和 7000 倍。

SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1.

SB 218795 (3-30 nM) antagonizes the contractile responses senktide-induced in a surmountable and concentration-dependent manner[1].

In rabbits, SB 218795 (0.25-1 mg/kg; i.v.) inhibits NK3 receptor-mediated pupillary constriction by maximum inhibition of 78%[1].

174635-53-1

C25H20N2O3

396.44

Ethanol:5 mM
DMSO:100 mMmg
Powder: -20°C for 3 years
In solvent: -80°C for 2 years