Eledoisin 是一种特异性的NK2和NK3受体的激动剂。

Eledoisin is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.

Eledoisin increases the value recorded under basal conditions by 24.5±3.7%; while this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P< 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively[1].

Injection of Eledoisin (0.1-1 nmol/kg) into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg).

69-25-0

C54H85N13O15S

1188.4

依来多辛;Eledone peptide

H2O:18.15 mg/mL (15.27 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years