Naftopidil hydrochloride 是一种选择性的 alpha1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，对克隆的人类 α1a、α1b和 α1d亚型肾上腺素受体的亲和力Ki分别为 3.7 nM、20 nM、1.2 nM。它具有抗增殖活性，可用于研究前列腺增生。

Naftopidil hydrochloride is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.

Naftopidil hydrochloride reduced the extent of lung fibrosis and SP‐D production in bleomycin‐induced lung fibrosis in mice[1].

Naftopidil hydrochloride strongly suppressed cell proliferation of stromal cells, resulting in decreased tumorigenic soluble factor, suggesting that naftopidil might be effective in preventing stromal support of tumor cells[2].

1164469-60-6

C24H29ClN2O3

428.96

1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-;萘哌地尔盐酸盐;BM-15275 hydrochloride;KT-611 hydrochloride

DMSO:60 mg/ml (139.88 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years