Phenylephrine 是一种选择性的α1-肾上腺素受体激动剂，常用作减充血剂。

Phenylephrine is a selective α1-adrenoceptor agonist ( pKi: 5.86, 4.87 and 4.70 for α1D, α1B, and α1A receptors respectively).

Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca(2+)/CaN/NFAT pathway mediates Phenylephrine-induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis [1][2][3].

Phenylephrine could enhance the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema. Perfusion of hearts with Phenylephrine (100 μM) induces a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α1-adrenoceptor agonists such as Phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes [4][5].

59-42-7

C9H13NO2

167.21

L-Phenylephrine;去氧肾上腺素碱;去氧肾上腺素;(R)-(-)-Phenylephrine

H2O:50 mg/mL (245.50 mM),Need ultrasonic
DMSO:150 mg/mL (736.49 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years