ABT 724 trihydrochloride 是一种有效的选择性 D4 受体激动剂（EC50 = 12.4 nM，14.3 nM 和 23.2 nM，分别对人、大鼠和雪貂）。 ABT-724 trihydrochloride 可用于勃起功能障碍研究。

ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies.

A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT 724 trihydrochloride(10 μM) exhibits a selective biochemical profile, as indicated by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors. ABT 724 trihydrochloride(10 μM) does not inhibit the PDE activity of PDE1, PDE5, or PDE6[1].

In male adult Wistar rats, ABT 724 trihydrochloride (8.8 μg/kg; s.c.) treatment facilitated penile erection in a dose-dependent manner[1].

587870-77-7

C17H22Cl3N5

402.7

DMSO:15 mg/mL (37.24 mM),Need ultrasonic
H2O:100 mg/mL (248.29 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years