Saclofen 是竞争性GABAB受体拮抗剂(IC50:7.8 μM)。它可研究 GABAB受体调节大脑中缓慢抑制性突触后电位的功能。

Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain.

CCT241736 significantly inhibited the growth of MV4-11 human FLT3-ITD positive AML tumor xenografts in vivo, with biomarker modulation and free drug exposure consistent with dual FLT3 and Aurora kinase target inhibition

125464-42-8

C9H12ClNO3S

249.71

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years