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Lorediplon
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lorediplon图片
CAS NO:917393-39-6
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Lorediplon 是一种新型催眠药物,作为 GABAA 受体调节剂,在 α1 亚基上具有差异活性,与促进睡眠有关。

产品描述

Lorediplon is a novel hypnotic drug acting as a GABAA receptor modulator, differentially active at the α1-subunit, associated with promoting sleep.

体内活性

In vivo, Lorediplon inhibits spontaneous motor activity and increases the duration of sleep in mice (ED50s = 0.13 and 1.2 mg/kg, respectively). It selectively inhibits spontaneous motor activity, which is driven by α1 subunit-containing GABAA receptors, over modification of muscular tone in mice, an α2 subunit-containing GABAA receptor-stimulated activity [1]. Lorediplon (0.13 and 1.2 mg/kg) also decreases latency to slow-wave sleep (SWS) and paradoxical sleep (PS) in mice [2].

Cas No.

917393-39-6

分子式

C20H15FN4O2S

分子量

394.42

储存和溶解度

DMSO:100 mg/mL (253.54 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years