Isoguvacine hydrochloride 是 GABA 受体激动剂。它与大鼠突触皮质膜结合并激活 α1β2γ2S、α2β2γ2S、α3β2γ2S、α5β2γ2S 和 ρ1 亚基 GABAA 受体。

Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.

Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events[2]. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus[3].

68547-97-7

C6H10ClNO2

163.6

1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride;异四氢烟酸

H2O:90 mg/mL (550.12 mM)
DMSO:20 mg/mL (122.25 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years