RWJ-51204 is a partial agonist of GABA(A) receptor (Ki: 0.2-2 nM).

RWJ-51204 binds to receptors with Ki ranging from 0.2 to 0.6 nM in the cerebral cortex, cerebellum, or medulla-spinal cord.

RWJ-51204 is effective in the conflict test in monkeys (ED50 of approximately 0.5 mg/kg p.o.). RWJ-51204 is orally active in anxiolytic efficacy tests. RWJ-51204 effectively impairs rotarod performance in rats (ED50 = 0.12 mg/kg), and all rats given RWJ-51204 orally at 30 mg/kg exhibit sedation, reduced skeletal muscle tone, and impairment of rotarod performance.

205701-85-5

C21H19F2N3O3

399.39

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years