L-655708 is an effective inverse agonist of the α5 subunit-selective GABAA receptor (Ki: 0.45 nM).

L-655708 is an agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki: 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 orα6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

L-655708 (0.7 mg/kg) administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects.

130477-52-0

C18H19N3O4

341.36

DMSO:20 mg/mL (58.59 mM),Need ultrasonic
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years