Brofaromine (CGP 11305A) is an MAO inhibitor (IC50: 0.2 μM for MAO-A).

In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine is determined on the activity of MAO-A in cultured cortical cells. The cultured cortical cells have significant MAO-A activity. Brofaromine inhibits the enzyme in a concentration-dependent manner (IC50: 0.19?μM). Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10?μM. Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC50 range of Brofaromine is 0.01?μM to 0.1?μM.

63638-91-5

C14H16BrNO2

310.19

CGP 11305A

DMSO:250 mg/mL (805.96 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years