Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (Kd: 16.5 and 64.4 nM, respectively).

Ro 41-1049 (20 mg/kg) pretreatment significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing the formation of 3,4-dihydroxyphenylacetic acid and homovanillic acid. Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion [2].

127917-66-2

C12H13ClFN3OS

301.77

DMSO:32 mg/mL (106.04 mM)
H2O:25 mg/mL (82.84 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years