AR-M 1896 Acetate 是 GalR2 的选择性激动剂。

AR-M 1896 Acetate is the selective agonist of GalR2.

Removal of the glycine residue in position 1 resulted in AR-M1896 with almost unchanged GalR2 affinity and functional activity, and 500-fold selectivity for GalR2-Rs over GalR1-Rs[1].?

In normal rats mechanical and cold allodynia of the hindpaw are induced by intrathecal infusion of low-dose galanin. The same effect is seen with equimolar doses of AR-M1896 or AR-M961 (an agonist both at GalR1 and GalR2 receptors). In allodynic Bennett model rats, the mechanical threshold dose-dependently increased after intrathecal injection of a high AR-M961dose, whereas no effect was observed in the control or AR-M1896 group. No effect of either compounds was observed in nonallodynic Bennett model rats[1].

T21646L

C56H85N13O16

1196.35

AR-M 1896 Acetate (367518-31-8 Free base)

DMSO:55 mg/ml (45.97 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years