LY2444296 是 kappa Opioid Receptor (Ki = 1 nM) 的具有口服活性的和选择性拮抗剂。

LY2444296 is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).

LY2444296 reduces anxiety-like and depressive-like behaviors, and CORT release, in rats tested after chronic extended access cocaine self-administration. In cocaine-naive adult male Sprague Dawley rats, LY2444296 (3 mg/kg; i.p.) prevents behavioral and neuroendocrine effects caused by U69,593[2].

1346133-11-6

C24H22F2N2O2

408.44

FP3FBZ

Ethanol:25.2mg/mL (61.7mM),Need ultrasonic
Methanol:5 mg/mL (12.24 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years