[(pF)Phe4]Nociceptin(1-13)NH2 acetate 是一种选择性 NOP 受体激动剂，pKi 为 10.68，pEC50 为 9.31。 [(pF)Phe4]Nociceptin(1-13)NH2 acetate 对 δ、κ 和 μ 阿片受体具有高选择性（>3000 倍）。

[(pF)Phe4]Nociceptin(1-13)NH2 acetate is a selective agonist of NOP receptor with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 acetate displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold).

In unanaesthetised normotensive mice, [(pF)Phe4]Nociceptin(1-13)NH2 acetate (100 nmol/kg; i.c.v.) dose-dependently stimulated feeding in rats and is about tenfold more potent than NC(1-13)NH2. [(pF)Phe4]Nociceptin(1-13)NH2 acetate (100 nmol/kg; i.v.) decreases mean blood pressure and heart rate; these effects are longer lasting than those elicited by the same dose of NC(1-13)NH2[1].

TP1885L1

C63H103FN22O17

1459.63

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years