Naloxone HCl Dihydrate 是一种阿片类反向激动剂药物，用于对抗阿片类药物过量的影响。

Naloxone HCl Dihydrate is an opioid inverse agonist drug used to counter the effects of opiate overdose.

The Ki values of (?)-naloxone for the MOR, KOR, and DOR are 0.559 nM, 4.91 nM, and 36.5 nM, respectively. Naloxone HCl Dihydrate binds to the MOR with approximately 9-fold greater affinity relative to the KOR and around 60-fold greater affinity relative to the DOR.[1]

The combination of Naloxone HCl Dihydrate (0.5 mg/kg, i.p.) with tramadol (22 mg/kg) decreases the antiallodynic effect of tramadol. [2]

51481-60-8

C19H26ClNO6

399.87

Naloxone hydrochloride dihydrate;二水合盐酸纳洛酮

Ethanol:<1 mgml
H2O:16 mg/mL (40 mM)
DMSO:73 mg/mL (182.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years